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Caprelsa 300mg is a type of targeted therapy called a tyrosine kinase inhibitor. A kinase is an enzyme which help to cell growth and it acts by targeting receptors present on the cancer cells.
Caprelsa 300mg targets epidermal growth factor (EGFR) and vascular endothelial growth factor receptors (VEGF).
Caprelsa 300mg is a prescription drug which is used under the guidance of medical practioners
The Caprelsa 300mg is used for the therapy of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.
Vandetanib is a group of cancer-fighting medications known as anticancer and more especially to a class of medications called receptor tyrosine kinase inhibitors. These medications are antitumor medications which reduces the growth of blood vessels which fodder nutrients to cancer cells. By reducing the growth of these blood vessels, Vandetanib can help decrease the tumors sizes, which are collections of cancer cells. Vandetanib also works directly on cancer cells to destroy them or slow down the speed at which they grow.
Time to high plasma level is 6 hr (range 4-10 hr) and steady state is 3 months
Bounding of plasma protein is 90% and volume of distribution is 7450L
Caprelsa 300mg is metabolized by CYP3A4
The drug elimination through feces 44% and via urine collection period of 21 day after single dose.
The Caprelsa prescribed dose is 300mg administrated orally once daily until disease progression or unacceptable toxicity occurs
Do not crush the tablets, disperse the tablet in 2 ounces of water by stirring 10 minutes approximately.
Be careful, do not use other liquids for dispersion and swallow the medicine soon after dispersion, if any remaining residue with 4 additional ounces of water and swallow.
Th dispersion liquid can be administrated via nasogastric or gastrostomy tubes.
While interaction with a strong CYP3A4 inducer will decreased Vandetanib plasma concentration. Hence avoid concomitant use of known strong CYP3A4 inducers during Caprelsa 300mg treatment.
When patients getting Caprelsa 300mg with drugs that are transported by OCT2 will increased plasma concentration of metformin.
When patients getting Caprelsa 300mg with digoxin will increased plasma concentration of digoxin.
Avoid Interaction of Caprelsa 300mg with agents which may prolong the QT interval.
Congenital long QT syndrome.
Caprelsa 300mg is embryotoxic and fetotoxic, due to pharmacological action treatment will causes harm to fetal when administered to a pregnant woman
Advise females not to breastfeed during treatment and for 4 months after final dose.
Caprelsa 300mg tablets should be stored at 250C.
If dose is failed to take, then have the dose immediate before reach of next dose time or swap the missed dose and follow the normal schedule. Do not have extra dose which leads to over dosage. Avoid taking missed dose within 12 hours of the next dose.
Must Consult the doctor about missed dose and overdose
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